1-methyl-4-phenylpyridinium

名词 n.
中文释义

英文释义

名词 n.
  1. MPP+, the active metabolite of MPTP. uncountable
    — 2006, Zhang et al, Investigative Opthamological and Visual Science http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16384975&query_hl=14&itool=pubmed_docsum Apical uptake was higher than basolateral uptake at 37 degrees C and was decreased to 70% in the presence of NaN(3) or in the absence of extracellular Na(+). Besides alpha2-agonists, apical uptake was inhibited by verapamil, desipramine, and quinidine, but not by MPP(+) (1-methyl-4-phenylpyridinium), TEA (tetraethylammonium), decynium-22, carnitine, PHA (p-aminohippurate), alanine, or inosine.
  2. A neurotoxin that cannot cross the blood-brain barrier but which, once in contact, can destroy the dopaminergic neurons of the substantia nigra. uncountable
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