binimetinib

名词 n.
英 /bɪnɪˈmɛtɪnɪb/    美 /bɪnɪˈmɛtɪnɪb/|[-ɾə-]

英文释义

名词 n.
  1. A drug with the molecular formula C₁₇H₁₅BrF₂N₄O₃ that inhibits mitogen-activated protein kinase kinase (MEK), and is approved for use in combination with encorafenib to treat certain melanomas. uncountable
    — Binimetinib (MEK162; ARRY-438162) is a potent, adenosine triphosphate-uncompetitive, highly selective allosteric inhibitor of MEK1/2 with demonstrated on-target activity in vitro and in vivo, including models of cancer [...] In vivo, binimetinib displays broad anti-tumour activity in xenograft models derived from melanoma, colorectal cancer, non-small cell lung cancer (NSCLC), fibrosarcoma, cholangiocarcinoma, and pancreatic cancer. These non-clinical data support the use of binimetinib in a wide variety of tumour types, with a priority in tumours with aberrantly activated MAPK pathway signalling.

词源

From bini- (a unique prefix) + -metinib (suffix indicating an inhibitor of mitogen-activated protein kinase kinase (MEK)).
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