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双语:睡眠不足会引发全身炎症吗?

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双语:睡眠不足会引发全身炎症吗?

  • According to recent research, prolonged sleep loss can lead to severe inflammatory responses in the body, and may even result in death. Specifically, lack of sleep increases the levels of prostaglandin D2 (PGD2) in the brain, which, when expelled into the bloodstream across the blood-brain barrier, can induce the aggregation of circulating neutrophils and a cytokine storm syndrome, causing serious pathological consequences for the peripheral immune system. This inflammatory response is similar to the "cytokine storm" seen in severe cases of COVID-19, which can lead to multiple organ dysfunction syndrome (MODS).   In a study published in the journal Cell, researchers found that mice deprived of sleep for an extended period had a 70% or higher mortality rate within four days due to severe organ failure. The mice experienced a rapid accumulation of pro-inflammatory cytokines (such as IL-6 and IL-17A) and chemokines (such as CXCL1 and CXCL2) in their blood, leading to the recruitment of neutrophils from the bone marrow to the circulatory system, ultimately resulting in MODS.   This research underscores the importance of sleep in maintaining the balance of the immune system and provides new scientific evidence for explaining and addressing health issues caused by sleep deprivation. Therefore, ensuring adequate sleep is crucial for overall health maintenance.

    根据最新的研究,长时间睡眠剥夺会导致生物体出现严重的炎症反应,甚至可能导致死亡。具体来说,睡眠不足会增加大脑中前列腺素D2(PGD2)的水平,这种物质通过血脑屏障外排到血液循环中,会诱发循环中性粒细胞的聚集和细胞因子风暴综合症,从而给外周免疫系统带来严重的病理后果。这种炎症反应与人体在新冠重症中出现的“细胞因子风暴”类似,可能导致多器官功能障碍综合征(MODS)。   在一项发表在《Cell》杂志上的研究中,研究人员发现,长时间睡眠剥夺的小鼠在4天内有高达70%以上死于严重的多器官衰竭。这些小鼠血液中的促炎细胞因子(如IL-6和IL-17A)和趋化因子(如CXCL1和CXCL2)迅速积累,导致中性粒细胞从骨髓被招募到循环系统中,最终导致多器官功能障碍综合征(MODS)。   这项研究强调了睡眠对维持免疫系统平衡的重要性,并为解释和解决睡眠不足导致的健康问题提供了新的科学依据。因此,保证充足的睡眠对于维护整体健康至关重要。
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